Don Champagne seems to have it all: a successful business, a perfect house, perfect kids and a perfect wife. Unfortunately, when his wife, Mona (Katherine Heigl), learns of Don's affair with a pretty new salesgirl (Jordana Brewster), this suburban slice of heaven spirals out of control. Don soon realizes that Mona will stop at nothing, including murder, to maintain their storybook life where "perception is everything".

A group of friends stop to pick up a hitchhiking woman only to end up getting drugged by her with a gas. They awaken to find that vials have been implanted in the base of their skulls - which are of course instantly fatal if they are removed, a grinning professional looking woman informs them on TV screens that they have 22hrs to fill these vials with a specific amount of brain fluid, a fluid that is produced during times of extreme pain. Along with another group of unlucky test subjects and with time ticking away they decide to work together and share the burden of reaching their painful target.

A rebellious girl hooks up with an escort agency where her stepfather is a client.